SYNVISC

SYNVISC is a sterile gel:
- Viscoelastic based on hylan G-F 20, a sodium hyaluronate derivative, for intra-articular injection.
- Clear, slightly yellow, viscous and transparent, with no visible particles.
- It relieves pain and improves mobility in joints.

- SANOFI
- NAME: SYNVISC
- COMPOSITION: Sodium salt of hyaluronic acid, N-acetylglucosamine, sodium glucuronate, hylan G-F 20, hylan A, hylan B, saline, sodium chloride.
- PRESENTATION: 3 x 2 ml.
- NEEDLE: Use 18-22 G needles for SYNVISC.
- INDICATIONS: Temporarily restores the viscoelasticity of synovial fluid. Provides clinical benefit to patients in all stages of joint arthrosis.
- INJECTION DEPTH: Intra-articular injections within the synovial cavity of the joint.
- DURATION: 6 to 12 months.
- USE: Strict medical use.

- Syringes: 3 x 2 ml.
- Each box contains three pre-filled disposable glass syringes of SYNVISC.

SYNVISC TREATMENT ZONES
Ideal for arthrosis, cartilage deficiency and weak joints (knee, hip, shoulder, ankle).

Sodium salt of hyaluronic acid, N-acetylglucosamine, sodium glucuronate, hylan G-F 20, hylan A, hylan B, saline, sodium chloride.

- The efficacy of a course of treatment consisting of less than three injections (2 mL each) of SYNVISC has not been established.
- The safety and efficacy of SYNVISC at sites other than the knee and for diseases other than osteoarthritis have not been established.
- The safety and efficacy of using SYNVISC concomitantly with other intra-articular injectables have not been established.
- Use caution when injecting SYNVISC in patients allergic to proteins of avian origin, feathers or egg products.
- The safety and efficacy of SYNVISC in knee joints with severe inflammation have not been established.
- Strict adherence to an aseptic administration technique is required.
- Sterile content. The syringe is intended for single use only. The contents must be used immediately after opening the package. Discard any unused quantities of SYNVISC.
- Do not use SYNVISC if the packaging has been opened or damaged. Store in the original packaging (protected from light) at room temperature below 30 °C. DO NOT FREEZE.
- Remove any synovial fluid or effusion before each injection of SYNVISC.
- SYNVISC should be used with caution in patients with signs of lymphatic or venous stasis in the limb to be treated.

- Do not administer to patients with known hypersensitivity (allergy) to hyaluronan (sodium hyaluronate) preparations.
- Do not inject SYNVISC into the knees of patients with knee joint infections or skin diseases/infections in the area of the injection site.

SYNVISC is to be used in cases of topical difficulties of the locomotor system, particularly the osteo-articular system. It is indicated for arthralgia, joint stiffness, joint effusion, joint swelling, arthritis, arthropathy, gait disturbance.